Nolvadex is a hormone antitumor medicine. It is prescribed during a long-term maintaining therapy in patients with breast cancer, prostate cancer, endometrium, malignant tumors during menopause.
Nolvadex contains Tamoxifene. This ingredient binds to the receptors of estrogen in the tumor tissues and blocks their action. If tumor grows due to the stimulation of estrogens, a prescription of Nolvadex will stop this process.
A main task of Nolvadex is to stop a development of tumor for the maximally long period. The drug does not reduce tumor. It just slows its growth, so that patients’ quality life is increased, and a risk of death is reduced.
Nolvadex is often prescribed after the course with aromatase inhibitors. If they did not help, the use of Tamoxifene gives almost 100% result.
Nolvadex is produced in pills for oral use. The treatment should be long because a stable therapeutic effect is kept only due to the continuous treatment. A standard daily dose of Nolvadex is 20-40 mg. This dose effectively blocks receptors of estrogen in tumor and prevents it from growing. The treatment may last for up to 5-6 years. After this period the efficiency of a therapeutic action drops and other methods of the treatment are required.
A medical examination should be regularly done during the treatment (once in 3 months). If tumor tissue grows due to the use of Nolvadex 40 mg, the treatment is stopped.
In rare cases, women may need a higher daily dose. In these cases, a pill of Nolvadex 40 mg is prescribed 2 times per day. This way, the medicine is used for a short period.
Men take just 20 mg per day. The higher doses are not used because of the less number of the estrogen receptors in the tissues.
- You do not have to take the medicines containing estrogens or affecting synthesis of the female genitals during the treatment
- In case of the simultaneous use with medicines providing the effect on the blood coagulation system, a dose of Tamoxifen is adjusted
- The use of Nolvadex is contraindicated during leukopenia, thrombocytopenia, cataract, and severe diseases of the cardiovascular system
- Nolvadex is not prescribed during pregnancy. The use of the drug during pregnancy may cause permanent diseases and even miscarriage. If Nolvadex is prescribed during lactation, stop the breast-feeding
Due to a long-term treatment, the side effects of Nolvadex are light. Patients normally do not experience physiological or psychological discomfort.
But in case of an overdose, the side effects grow. Main symptoms of the overdose are skin allergic reaction, urticaria, edema, menstruation disorder, diarrhea, or vomiting. If these symptoms appear, go to a doctor and have a symptomatic therapy. A decrease of the dose helps to relieve a patient’s state. If the overdose was critical, the treatment is completely stopped.